Cushing’s
disease is named for Dr. Harvey Cushing, who originally diagnosed the
syndrome in a human in 1932. In veterinary medicine, the condition is
most often seen in dogs, especially Terriers, Poodles, Dachshunds and
the American Eskimo/Spitz. The disorder rarely occurs in cats.
The
medical name for Cushing’s is much more descriptive of the condition:
hyperadrenocorticism. Hyper means “too much,” adreno refers to the
adrenal glands and corticism refers to a syndrome involving the hormone
cortisol.
Hyperadrenocorticism, loosely translated, means “too much cortisol released by the adrenal glands.”
- Cushing’s disease, also called hyperadrenocorticism, is a condition primarily of dogs involving the chronic release of too much cortisol by the adrenal glands
- An overproduction of cortisol is called typical Cushing’s disease, and can be either adrenal dependent, or more commonly, pituitary dependent; “atypical” Cushing’s involves the overproduction of aldosterone or sex hormones
- Cushing’s syndrome can produce a variety of diverse symptoms, including increased thirst and urination, hair loss and weight gain around the abdomen
- Risk factors for atypical Cushing’s appear to include early spaying and neutering, and exposure to xenoestrogens and other external estrogen mimics
- It’s crucial to catch signs of Cushing’s early, before it becomes full-blown. Many pre-Cushing’s patients can be successfully treated with nutraceuticals, Chinese herbs, homeopathics, nutritional therapy and lifestyle management (reducing biologic stress)
Symptoms of Cushing’s Disease
In
excessive amounts, cortisol can create a host of diverse symptoms. Most
dogs have a few, but not all of the symptoms of the disorder unless
diagnosis comes very late in the course of the disease. The symptoms
most commonly seen in dogs with early Cushing’s include:
Treatment Options
Most
of the drugs currently available to treat Cushing’s disease have many
undesirable side effects. It’s extremely important to discuss your
concerns about possible side effects with your Veterinarian. It is
recommended you do your own research as well. Try to avoid using
Lysodren and other potent Cushing’s drugs because in the opinion of Dr.
Becker, the side effects are often worse than the symptoms the animal is
dealing with. Dr. Becker usually catches the disease in her own
patients before high drug doses are required.
How to Help Prevent Cushing’s in Your Pet
There are some common sense steps you can take to reduce your pet’s risk of developing hyperadrenocorticism, including:
Make Your Pets Healthier and Happier!
If
you love your pets and would do anything to give them the most
excellent health possible, do right by them and give them the best of
the best.
LIGNANS (PHYTONUTRIENTS)
Source
Currently, the lignans on the market: lignan that is derived from the Norwegian Spruce tree.
Currently, the lignans on the market: lignan that is derived from the Norwegian Spruce tree.
The active ingredient of is 7-hyroxymatairesinol (7HMR). Lignans is extracted from the Norwegian Spruce tree, and yields high amounts of 7HMR. Once ingested, it is directly converted by gastrointestinal bacteria into the major-endogenous-mammalian lignan (enterolactone). Lignans forms more enterolactone than flax hull lignan, since another endogenous-mammalian lignan called enterodiol, is formed by SDG lignan, and is less bioactive in systemic tissues compared to enterolactone. Cleavage of sugar chains must occur for SDG flax hull lignan, by the intestinal bacteria, before the mammalian lignans are formed. This may or may not offer efficacy advantages to 7HMR (further research will be needed to prove or disprove this). Blood levels of 7HMR remain adequate for 24 hours on once-daily-dosing. 7HMR reportedly is readily and completely absorbed from the gastrointestinal tract (SDG lignan is not completely absorbed, although adequate blood levels do occur from dosages used). Thus, better bioavailability and more rapid uptake occurs for enterolactone formed from 7HMR. Since 7HMR’s bioavailability to the body is better than SDG flax hull lignan, this allows reduced doses to be used.
Adverse Effects
SDG lignan, having fiber as a component, can cause increase in stool frequency (and occasionally diarrhea).7HMR contains very little (if any) fiber, so this side effect should not be seen with 7HMR.
SDG lignan, having fiber as a component, can cause increase in stool frequency (and occasionally diarrhea).7HMR contains very little (if any) fiber, so this side effect should not be seen with 7HMR.
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