- Cushing’s disease, also called hyperadrenocorticism, is a condition primarily of dogs involving the chronic release of too much cortisol by the adrenal glands
- An overproduction of cortisol is called typical Cushing’s disease, and can be either adrenal dependent, or more commonly, pituitary dependent; “atypical” Cushing’s involves the overproduction of aldosterone or sex hormones
- Cushing’s syndrome can produce a variety of diverse symptoms, including increased thirst and urination, hair loss and weight gain around the abdomen
- Risk factors for atypical Cushing’s appear to include early spaying and neutering, and exposure to xenoestrogens and other external estrogen mimics
- It’s crucial to catch signs of Cushing’s early, before it becomes full-blown. Many pre-Cushing’s patients can be successfully treated with nutraceuticals, Chinese herbs, homeopathics, nutritional therapy and lifestyle management (reducing biologic stress)
Symptoms of Cushing’s Disease
How to Help Prevent Cushing’s in Your Pet
Make Your Pets Healthier and Happier!
Currently, the lignans on the market: lignan that is derived from the Norwegian Spruce tree.
The active ingredient of is 7-hyroxymatairesinol (7HMR). Lignans is extracted from the Norwegian Spruce tree, and yields high amounts of 7HMR. Once ingested, it is directly converted by gastrointestinal bacteria into the major-endogenous-mammalian lignan (enterolactone). Lignans forms more enterolactone than flax hull lignan, since another endogenous-mammalian lignan called enterodiol, is formed by SDG lignan, and is less bioactive in systemic tissues compared to enterolactone. Cleavage of sugar chains must occur for SDG flax hull lignan, by the intestinal bacteria, before the mammalian lignans are formed. This may or may not offer efficacy advantages to 7HMR (further research will be needed to prove or disprove this). Blood levels of 7HMR remain adequate for 24 hours on once-daily-dosing. 7HMR reportedly is readily and completely absorbed from the gastrointestinal tract (SDG lignan is not completely absorbed, although adequate blood levels do occur from dosages used). Thus, better bioavailability and more rapid uptake occurs for enterolactone formed from 7HMR. Since 7HMR’s bioavailability to the body is better than SDG flax hull lignan, this allows reduced doses to be used.
SDG lignan, having fiber as a component, can cause increase in stool frequency (and occasionally diarrhea).7HMR contains very little (if any) fiber, so this side effect should not be seen with 7HMR.